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甲基苯丙胺的神经毒性及对GFAP表达的研究 被引量：3

Neurotoxicity and GFAP expression of Methamphetamine
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摘要 目的　探讨甲基苯丙胺 (MA)的神经毒性及胶质纤维酸性蛋白 (GFAP)的表达。方法　设立对照组和实验组 ,实验组予MA ,对照组予等体积生理盐水。采用HPLC测定不同脑区DA和 5 -HT的含量 ,用免疫组织化学方法检测GFAP的表达。结果　给予MA后 ,大鼠额叶皮层和纹状体的 5 -HT和DA均有下降 ;但对海马DA的影响不明显 ,对GFAP蛋白的表达明显上调。结论　MA对中枢 5 -HT、DA系统具有明显的神经毒性 ,并导致GFAP表达的上调。 OBJECTIVE To explore the neurotoxicity and glial fibrillary acidic protein(GFAP) expression of methamphataminc(MA).METHODS Rats were randomly dicidedints control group(A) and experimental group(B).Rats of group B were ip with MA,rats of group A were injected with saline.DA and 5-HT were measured by HPLC,and the expression of GFAP were detected by immunohistochemistry.RESULTS MA caused decrease of 5-HT and DA in rat frontal cortex and striatum,but it had no significant influence on the DA of hippocampus;The expression of GFAP was up-regulated significantly.CONCLUSION MA caused neurotoxicity to 5-HT and DA system of CNS and up-regulated the expression of GFAP.
作者 王雪 康林 李素霞 孙学礼 李静 祝三平
机构地区 四川大学华西医院精神科 成都云克药业有限公司
出处 《华西药学杂志》 CAS CSCD 2004年第3期170-172,共3页 West China Journal of Pharmaceutical Sciences
基金 四川大学华西医院基金资助
关键词 甲基苯丙胺 MA 神经毒性 GFAP表达 胶质纤维酸性蛋白 Methamphetamine Neurotoxicity GFAP
分类号 R965 [医药卫生—药理学] R979.1 [医药卫生—药品]
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参考文献5

  • 1Davidson C,Gow AJ,Lee TH,et al.Methamphetamine neurotoxicity:necrotic and apoptotic mechanisms and relevance to human abuse and treatment[J].Brain Res Brain Res review,2001,36:1
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同被引文献55

  • 1曾晓锋,路钢,李桢.甲基苯丙胺致多巴胺能神经元毒性机制的研究进展[J].中国法医学杂志,2010,25(1):33-36. 被引量：19
  • 2王雪,彭祖贵,况伟宏,李素霞,李静,孙学礼,黄明生.3,4亚甲基二氧基甲基苯丙胺神经毒性的实验研究[J].中国临床康复,2004,8(31):6916-6917. 被引量：5
  • 3李素霞,孙爱民,王雪,李静,彭祖贵,况伟宏,黄明生.MDMA神经毒性机制——氧化应激损害的初步研究[J].四川大学学报（医学版）,2006,37(2):191-195. 被引量：2
  • 4李学锋,邱平明,金贺,刘明,王慧君.甲基苯丙胺对相关脑区的神经毒性作用[J].解剖学杂志,2007,30(1):63-65. 被引量：20
  • 5Seiden LS,Ricaurte GA.Neurotoxicity of methamphetamine and related drugs[D].In Mehzer HY,Ed.Psychopharmacology:The Third Generation of Progress[C].New York:Raven Press,1987,359-366.
  • 6Gibb JW,Hanson GR,Johnson M.Neurochemical mechanisms of toxicity[D].In Cho AK,Segal DS,Eds.Amphetamine and its Analogs Psychopharmacology Toxicology and Abuse[C].San Diego,CA:Academic Press,1994,269-296.
  • 7Truong JG,Wilkjns DG,Baudys J,et al.Age-dependent methamphetamineinduced alterations in vesicular monoamine transporter-2 function:implications for neurotoxicity[J].J Pharmacol Exp,Ther,2005,314:1087-1092.
  • 8National Toxicology Program.NTP-CERHR monograph on the potential human reproductive and developmental effects of amphetamines[J].NTP CERHR MON,2005,16:vii-III1.
  • 9Bowyer JF,Holson RR.Methamphetamine and amphetamine neurotoxicity[D].In Chang LW,Dyer RS,Eds.Hand book of Neurotoxicology[C].New York:Marcel Dekker Inc,1995,845-870.
  • 10Seiden LS.Sabol KE.Neurotoxicity of methamphetamine-related drags and cocaine[D].In Chang LW,Dyer RS,Eds.Handbook of Neurotoxicology[C].New York:Marcel Dekker Inc,1995,825-843.

引证文献3

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华西药学杂志
2004年 第3期

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