摘要
目的 比较两种盐酸二甲双胍制剂在人体内的吸收。方法 采用RP -HPLC法测定两种制剂给药后的血药浓度。结果 在测定方法与给药量相同的情况下 ,肠溶片的血药浓度数据不完整。结论 肠溶片在胃肠道的吸收不完全。
OBJECTIVE To study the absorption of Metformin hydrochloride.METHODS The plasma concentrations of Mer formin hydroxhloride were determined by RP-HPLC after the two kinds of preparation were administrated in volunteers.RESULTS The concentrations were incomplete for enteric-coated Metformin Hydrochloride tablets after the same doses were administrated.CONCLUSION The absorption of enteric-coated Metformin hydrochloride in gastrointestinal tract is incomplete.
出处
《华西药学杂志》
CAS
CSCD
2004年第3期179-181,共3页
West China Journal of Pharmaceutical Sciences
关键词
盐酸二甲双胍制剂
肠溶片
血药浓度
MFH
Metformin hydrochloride
Plasma concentration
Absorption
Enteric-coated tablet
