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HSV-tk/GCV系统治疗恶性肿瘤研究进展 被引量:3

Advanced in HSV-tk/GCV system for the treatment of malignant tumor
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摘要 自杀基因治疗恶性肿瘤是国内外研究的热点。因其独有的旁观者效应 ,可克服基因转导率低的缺陷 ,并可与其他方法联合应用 ,通过靶向调控机制增强疗效 ,是较为有效且具有临床应用前景的基因疗法。现综述近年来HSV tk
出处 《国外医学(肿瘤学分册)》 2004年第6期422-425,共4页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 0 1712 0 1)
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  • 1Kwon GY, Jeong J, Woo JK, et al. Co-expression of bfl- 1 enhances host response in the herpes simplex virus-thymidine kinase/ganciclovir gene therapy system Co-expression of bfl-1 enhances host response in the herpes simplex virus-thymidine kinase/gancicl
  • 2Barzon L, Bonaguro R, Castagliuolo I, et al. Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer. J Clin Endocrinol Metab, 2002 , 87(11):5304-5311.
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  • 6Kanazawa T, Mizukami H, Okada T, et al. Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice. Gene Ther, 2003,10 ( 1 ): 51-58.
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