非小细胞肺癌耐药相关因子研究进展
Progress of determinants of chemo-resistance in non-small cell lung caner
摘要
非小细胞肺癌 (NSCLC)化疗有效率有待提高 ,阐明其耐药机制有助于问题的解决 ,并可能提供新的治疗靶点。核酸损伤修复能力、凋亡通路的改变以及部分关键因子的表达变化 ,被认为是其主要机制。
出处
《国外医学(肿瘤学分册)》
2004年第6期450-453,共4页
Foreign Medical Sciences (Cancer Section)
参考文献21
-
1Tsai CM, Chang KT, Li L, et al. Interrelationships between cellular nucleotide excision repair, cisplatin cytotoxicity, HER-2/neu gene expression, and epidermal growth factor receptor level in non-small cell lung cancer cells. JpnJ Cancer Res, 2000, 91(2)
-
2Font A, Taron M, Rosell R, et al. UGT1a1 genotyping correlates with toxicity and survival in non-small-cell lung cancer (NSCLC)patients treated with second-line CPT-11/docetaxol. Proc Am Soc Clin Oncol, 2001, 20: 340a.
-
3Bergman AM, Pinedo HM, Talianidis I, et al. Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. Br J Cancer,2003, 88(12): 1963-1970.
-
4Kikuchi T, Dalgo Y, Katagiri T, et al. Expression profiles of nonsmall cell lung cancer on cDNA microarrays: identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs. Oncogene, 2003, 22(14): 2192-2205.
-
5Rosell R, Danenberg K, Gandara D, et al. Altered ERCC1 expression correlates with response to cisplatin (DDP) + gemcitabine (GEM) in non-small-cell lung cancer (NSCLC) patients (pts). Proc Am Soc Clin Oncol, 2001, 20: 326a.
-
6Heim MM, Eberhardt W, Seeber S, et al. Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines. J Cancer Res Clin Oncol, 2000, 126(4): 198-204.
-
7Hu Y, Cherton Horvat G, Dragowska V, et al. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapoutic activity against human lung cancer cells in vitro and in vivo.Clin Cancer Res, 2003, 9(7):2826-2836.
-
8Ferreira CG, van der Valk P, Span SW, et al. Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. Ann Oncol,2001, 12(6): 799-805.
-
9Monzo M, Rosell R, Sanchez J J, et al. Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations. J Clin Oncol, 1999, 17(6): 1786-1793.
-
10Nishio K, Nakamura T, Koh Y, et al. Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells. Cancer, 2001, 91(8): 1494-1499.
-
1张鹏,朱俊杰.耐药相关因子(Pgp、GSTπ和MT)在肺癌中的表达及其临床意义的研究[J].中国肿瘤临床,2002,29(8):596-599. 被引量:3
-
2张毅,郑玲.非小细胞肺癌耐药相关因子与个体化治疗的研究进展[J].现代临床医学,2012,38(3):165-168.
-
3郭颖,赵丽霞,张林西,金春亭,范婕,李秀娟,白美玲.结直肠腺癌中耐药相关因子的表达及意义[J].临床与实验病理学杂志,2015,31(10):1167-1169. 被引量:3
-
4张钰,杜鲁巴,孙浩然,钦伦秀.肿瘤分子靶向治疗的研究进展[J].复旦学报(医学版),2016,43(1):115-121. 被引量:10
-
5韩杰,檀碧波,吕炳蓉,耿玮,赵建辉,何春年.胃癌与大肠癌原代细胞培养化疗药物敏感性的对比[J].中华普通外科杂志,2008,23(6):464-465. 被引量:10
-
6于晓勇,曹红霞,罗真.骨肉瘤治疗的研究进展[J].中国医药指南,2014,12(26):77-78. 被引量:6
-
7李霞.新辅助化疗在宫颈癌治疗中的应用效果观察[J].山西医药杂志,2016,45(10):1180-1182. 被引量:7
-
8瞿全新.卵巢癌多药耐药机制的研究进展[J].国外医学(妇产科学分册),2001,28(3):169-172.
-
9郑华,侯毅,戴明明.局部复发或转移直肠癌26例三维适形放疗[J].福建医药杂志,2008,30(2):56-56.
-
10陈怡东,邱晓光.大脑胶质瘤病的治疗现状[J].中国神经肿瘤杂志,2012,10(1):58-62. 被引量:5