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5-HT_(1D)受体调节大鼠偏头痛模型三叉神经二级神经元兴奋性 被引量：5

5-HT_(1D) Receptor Modulates the Activity of Second Neuron of Trigeminal Nerve in Migraine Model of Rat.
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摘要 目的 :探索 5 HT1D受体在偏头痛发病中的中枢角色。方法 :应用大鼠电刺激偏头痛模型 ,观察给予佐米曲普坦和BRL15 5 72后三叉神经脊束核尾段和上颈髓背角的c fos表达变化。结果 :佐米曲普坦明显抑制电刺激诱发的三叉神经脊束核尾段和上颈髓背角浅层神经元c fos表达 ,BRL15 5 72可拮抗佐米曲普坦的大部分抑制效应 ,单独BRL15 5 72对c fos表达无影响。结论 :5 HT1D受体在偏头痛模型中是调节三叉神经二级神经元兴奋的主要受体 ,曲坦类药物通过 5 HT1D受体抑制该神经元伤害性兴奋。 Aim:To investigate the central action of 5-HT 1D receptor in migraine.Methods:Migraine model of electrical stimulation is applied to observe the level of Fos expression in trigeminal nucleus caudalis (TNC)and upper cervical segments of cord (UCC)following administration of zolmitriptan and BRL15572 in rats.Results:Zolmitriptan inhibited the expression of c-fos induced by electrical stimulation in unilateral TNC(trigeminal nucleus caudalis) and UCC(upper cervical segments of cord ) dorsal horn superficial laminae and BRL15572(a high selective 5-HT 1D antagonists) can block most of the inhibiting effect of zolmitriptan;BRL15572 alone has no effect on the expression of c-fos.Conclusion:5-HT 1D receptor is the major receptor modulating the activity of second neuron of trigeminal nerve.Triptans can inhibit the nociceptive activity of neurons in TNC and UCC dosal horn via 5-HT 1D receptor.
作者 郭俊唐 于生元
机构地区 解放军总医院神经内科
出处 《中国临床神经科学》 2004年第2期159-160,166,共3页 Chinese Journal of Clinical Neurosciences
关键词 5-HT1D 受体 调节 偏头痛 三叉神经 二级神经元 兴奋性 migraine 5-HT 1D receptor c-fos BRL15572
分类号 R747.2 [医药卫生—神经病学与精神病学]
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参考文献8

  • 1Akin D,Gurdal H.Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery[J].Br J Pharmacol,2002,136(2):177-182
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二级参考文献9

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共引文献22

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二级引证文献38

中国临床神经科学
2004年 第2期

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