一锅法合成手性双噁唑啉化合物的改进

The Improvement of Synthesizing Chiral Bis(oxazoline) in One-pot

采用二异丙基乙基胺代替三乙胺吡啶作缚酸剂 ,在三苯膦、四氯化碳存在下 ,乙腈为溶剂 ,二元酸 1与L -苯丙氨醇一锅法反应得双口恶唑啉化合物 ,获得了最佳反应条件 ,反应收率为 60 .9% .

Bis(oxazoline) was synthesized by reacting diacid 1 L-phenylalaninol in one-pot method in the presence of Ph_(3)P and CCl_(4), acetonitrile as solvent and N, N-diisopropylethylamine instead of Et_(3)N-pyridine as a deacid reagent,the optiminium reaction condition was obtained and the yield was 60.9%.