幽门螺杆菌细胞毒素相关蛋白对儿童胃粘膜炎症的影响

The relation between Helicobacter pylor Cag A and children gastritis

目的 探讨幽门螺杆菌细胞毒素相关蛋白 (CagA)与儿童胃粘膜炎症程度之间关系。方法 采用免疫印迹法检测88例幽门螺杆菌相关性慢性胃炎患儿血清CagA抗体 ,并观察胃粘膜病理变化。 结果 88例幽门螺杆菌相关性慢性胃炎患儿血清CagA抗体阳性74例 ,阳性率84.09 % ,其中胃粘膜轻度炎症12例 (16.22% )、中重度炎症62例 (83.7 % ) ;而14例CagA抗体阴性患儿胃粘膜轻度炎症7例(50.00 % )、中重度炎症7例 (50.00% ) ,两组相比 ,差异有显著性 ( χ2=6.07 ,P<0.05)。 结论 产CagA的幽门螺杆菌能引起胃粘膜较重的炎症。

Objective To explore the relationship between HP CagA and gastritis of children. Methods Plasma antibody of CagA in88children with HP-associated chronic gastritis was detected by immunoblotting,and the pathologic alteration was observed meantime. Results Positive expression of CagA existed in74of all88cases(84.09%).12cases(16.22%)demonstrated mild gastritis and62case(83.78%)demonstrated moderate or severe gastritis.In the negative expression group,7cases(50.00%)demonstrated mild gastritis and7cases demonstrated moderate or severe gastritis.There is significant difference between the two groups(P<0.05). Conclusion HP that reproduce CagA can result in severe gastritis.