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实验性牙移动后三叉神经脊束核尾侧亚核CGRP的研究 被引量：2

The study of calcitonin gene related peptide in trigeminal subnucleus caudalis during experimental tooth movement
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摘要 目的: 研究实验性牙移动过程中,三叉神经脊束核尾侧亚核(Vc)内降钙素基因相关肽(CGRP)的改变。方法:在大鼠左侧上颌第一、二磨牙间塞入一弹性橡皮圈模拟临床正畸加力状态。于不同加力时间点对三叉神经脊束核尾侧亚核进行CGRP免疫组化染色。结果: 加力后6h和24h,实验侧三叉神经脊束核尾侧亚核CGRP样纤维明显少于对侧;施力3d后Vc浅层中CGRP 样阳性终末与对照侧无明显差异,加力后1w大于对侧,2w时恢复至对侧水平。结论:实验性牙移动引起CGRP在三叉神经脊束核尾侧亚核释放。 Objective: To observe changes in the distribution of the CGRP-immunnoreactive nerve fibers in trigeminalsubnucleus caudalis (Vc) during experimental tooth movement. Methods: Model of experimental tooth movement wasestablished by insertion of a separating elastic between the upper first and second molars to mimic clinical orthodontictooth movement. The immunohistochemical stain for CGRP in the Vc was carried out at diffent time. Results: The numberof CGRP-containing nerve fibers decreased significantly in experimental side of Vc at 6, 24 hours after tooth movement.There was no significant difference between the experimental and control sides at 3 day after tooth movement. The densityof CGRP immunoreactivity in experimental side was more than control side at 1 week after tooth movement and returnedto the control level at 2 week. Conclusion: Experimental tooth movement induces CGRP releasing in Vc.
作者 徐娟 刘洪臣 袁维秀 梁军 张庆诗
机构地区 解放军总医院口腔科 解放军总医院麻醉科
出处 《口腔颌面修复学杂志》 2004年第2期79-81,共3页 Chinese Journal of Prosthodontics
基金 全军医药卫生科研基金(02M013)
关键词 实验性牙移动 三叉神经脊束核尾侧亚核 CGRP 研究 tooth movement calcitonin gene-related peptide(CGRP) trigeminal subnucleus caudalis
分类号 R783 [医药卫生—口腔医学]
  • 相关文献

参考文献11

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二级参考文献21

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共引文献17

同被引文献25

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引证文献2

二级引证文献7

口腔颌面修复学杂志
2004年 第2期

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