胃癌组织环氧合酶-2表达与血管内皮生长因子的关系

Expression of COX-2 in gastric carcinoma and its relationship with VEGF

目的 观察胃癌环氧合酶-2和血管内皮生长因子的表达及相互关系。方法 应用免疫组化法检测胃癌组织COX-2和VEGF的表达状况。结果 32例胃癌中发现COX-2表达阳性22例(68.7％),其中伴淋巴结转移者COX-2表达阳性率80.9％(17/21),高于不伴淋巴结转移者的45.4％(5/11)(P<0.05)。而不同胃癌分期与组织类型之间COX-2表达无显著性差异(P>0.05)。32例胃癌中VEGF表达阳性20例(62.5％),其中COX-2阳性胃癌VEGF表达阳性率77.3％(17/22),而COX-2阴性胃癌VEGF阳性率30％(3/10),两组比较具有显著性差异(P<0.05)。结论 胃癌组织存在COX-2过度表达,且与VEGF表达相关。

Objective To study expressions of COX-2 and VEGF in gastric carcinoma and their relationship. Methods Expressions of COX-2 and VEGF were detected immunohistolochemically. Results COX-2 expression was detected in 22 out of 32 cases of gastric cancer,and the positive rate was 68.7% ,among which COX-2 expression rate was significantly higher in the cases with lymph node involvement (80.9%) than those without lymph node involvement (45 .4 % ) . However, there was no significant difference in COX-2 expression between early gastric cancers and advanced gastric cancers , the cases with serosa invasion and those without serosa invasion ,as well as among well-differentiated adenocarcinoma, mucous carcinoma and low-differentiated adenocarcinoma. Twenty out of all 32 cases were found to be positive in VEGF expression.The rate of VEGF expression in COX-2 -positive group(77.3%) was significantly higher than that in the negative group(30%) .Conclusion COX-2 is overexpressed in gastric carcinoma, which is correlated with VEGF expression.