复发转移乳腺癌(附34例报告)

Relapsed and metastatic breast cancer(report of 34 cases)

目的 探讨复发转移乳腺癌的临床病理特点 ,最佳治疗方法和治疗效果。方法 对3 4例复发转移乳腺癌病人 ,采取化疗 ,结合手术 ,放射治疗 ,术后继续化疗。结果 2 3例伴有内脏转移的 2个部位以上复发转移病人 ,经化疗病灶缩小明显 (PR) 7例 ,病情稳定 (SD ) 8例 ,病情进展(PD) 8例 ,临床获益 (CR +PR +SD) 65 % (15 / 2 3 )。 1年生存率 65 % ,11例局部复发化疗后病灶缩小 (PR) 10例 ,病情进展 (PD) 1例 ,临床获益 90 % (10 / 11) ,2年无瘤生存率 90 %。结论 伴有内脏转移的复发转移应以化疗为主 ,病灶缩小者 ,局部手术切除 ,放疗 ,术后继续化疗。显著延长生存时间。局部复发无内脏转移 ,也应先化疗 ,再手术 ,可减少远隔器官转移。

ObjectiveTo investigate the clinicopathologic characteristics,treatment and prognosis of relapsed and metastatic breast cancer.MethodsThirty-four cases of relapsed and metastatic breast cancer treated were summarized.ResultsAmong the 23 patients out of 34 cases of relapsed and metastatic breast cancer with metastasis of internal organs,rates of partial response was 30.4% (7/23),stable disease(SD)34.7%(8/23),progressive disease(PD)34.7%(8/23),and clinical benefit response(CR+PR+SD)65.2%(15/23).The one-year survival rate was 65.2%.Among these 11 patients with relapsed of local region,rates of partial response was 90%(10/11), PD 9% (1/11),clinical benefit response 90% and the two-gear survival rate was 90%.ConclusionThe patients with metastasis of internal organ should be treated by chemotherapy as the dominant factor.The patients with focus reduced should be treated by operation and radiotherapy next,and continuously subjected to chemotherapy after operation.The survival time was prolonged.The patients with relapse of local region should be first treated by chemotherapy,then operation,radiotherapy,which could decrease the metastasis of internal organs