早期隔离应激对大鼠视觉线索辨别学习和逆反学习的影响

The effect of early isolated stress on the visual discrimination learning and reversal learning in rats

目的探讨早期隔离应激对大鼠视觉线索辨别学习和随后的逆反学习的影响。方法出生后 2 1天的大鼠单笼隔离喂养 6周 ,然后利用旋转T迷宫装置 ,通过食物强化 ,分别训练大鼠视觉线索辨别学习和逆反学习任务。结果与正常喂养 ( 3只 /笼 )的对照组动物相比 ( 177± 3 1.2 6,3 3 3± 3 9.41) ,早期隔离应激的动物达到视觉线索辨别学习标准的学习次数 ( 198± 3 7.95 )无显著性差异 ,但达到逆反学习标准的学习次数 ( 4 17± 95 .95 )显著增加 (P <0 .0 5 )。结论早期隔离应激并不影响正常的视觉线索辨别学习任务 ,但干扰逆反学习任务的获得。

ObjectiveTo explore the effect of early isolated stress on the visual discrimination learning and reversal learning in rats. Methods Early isolated stress was performed from weaning (21 days of age) to adulthood, then through food rewarding rats were trained in a normal and reversal visual discrimination task in a rotating T-maze. Results For normal visual discrimination task, there was no significant difference between rats in control group (3 rats/cage) and isolation group, but for reversal learning, the number of trials of rats in early isolated stress group was significantly increased(P<0.05). Conclusion Early isolated stress had no effect on the normal visual discrimination learning, but disrupted the acquisition of reversal learning.