5-羟色胺2A受体基因多态性与精神分裂症质量性状和数量性状的关联分析

Association analysis between polymorphism in the serotonin 2A receptor gene and qualitative character and quantitative character of schizophrenia in Chinese

目的探讨 5 羟色胺 2A( 5 HT2A)受体基因T10 2C多态性与精神分裂症质量性状和数量性状之间的关系。方法随机抽取 81例精神分裂症患者及 88例正常对照 ,利用阳性与阴性症状量表(PANSS)来评定患者的临床症状 ;采用聚合酶链式反应 限制性片段长度多态性 (PCR RFLP)技术 ,检测精神分裂症患者及正常对照的基因型和等位基因频率 ,将所得资料进行 χ2 检验和方差分析。结果 5 HT2A受体基因T10 2C多态性与精神分裂症质量性状缺乏关联 ;与其阴性和阳性症状的数量性状缺乏关联 ,但与精神分裂症幻觉症状的数量性状存在关联 ,A1/A1基因型患者较A2 /A2 基因型者幻觉症状严重。结论 5 HT2A受体基因与精神分裂症及其阴性症状和阳性症状的发病机制可能无关 ,与幻觉症状的发病机制可能相关。

Objective To investigate the relationship between T102C polymorphism in the serotonin 2A(5-HT 2A)receptor gene and qualitative character and quantitative character of schizophrenia. Methods 81 patients with schizophrenia and 88 normal controls were studied. Patients' clinical symptoms were rated according to the Positive and Negative Symptom Scale (PANSS). The genotype and alleles in these patients and normal controls were examined with polymerase chain reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) technique. The significance for the association was estimated by χ 2and ANOVA. ResultsLack association between polymorphism in the 5-HT 2A receptor gene and qualitative character and quantitative character of schizophrenia and its negative symptoms or positive symptoms in Chinese. We found that association between polymorphism in the 5-HT 2A receptor gene and quantitative character of halluciation. The halluciation symptom of genotype A 1/A 1 is more serious than that of genotype A 2/A 2.ConclusionOur results suggest that 5-HT 2A receptor gene is not involved in the pathgenesis of schizophrenia or its negative and positive symptoms, but involved in the pathgenesis of halluciation symptom.