摘要
目的 进一步认识布洛芬与吲哚美辛治疗早产儿动脉导管未闭 (PDA)的疗效和不良反应的差异。方法 通过数据库检索出符合分析条件的有关吲哚美辛与布洛芬对照治疗早产儿PDA的研究报告 6篇 ,取其研究结果做Meta分析。结果 布洛芬与吲哚美辛治疗PDA的疗效相同 ,但布洛芬组出现少尿显著少于吲哚美辛组 ,其他不良反应无显著差异。结论 布洛芬治疗PDA的疗效与吲哚美辛相同 ,但引起肾脏不良反应少。
Objective To study the difference in therapeutic effects and side effects of ibuprofen versus indomethacin for symptomatic patent ductus arteriosus (PDA) in the premature infants.Methods Meta analysis was used to qualitatively and quantitatively evaluate the data extracted from 6 public papers about comparative study of ibuprofen and indomethacin.Results The rate of ductal closure was similar with the two treatment regimes (intravenous ibuprofen and indomethacin).In side effects on PDA,the incidence of oliguria induced by ibuprofen was significantly lower than that of indomethacin though there were no difference in other side effects.Conclusions The efficacy of ibuprofen for the early treatment of PDA in preterm infants is similar with indomethacin,and has low incidence of oliguria.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第6期489-491,共3页
Journal of Applied Clinical Pediatrics