老年慢性精神分裂症患者事件相关电位P_(300)改变的意义

THE ABNORMAL VARIATIONS OF AUDITORY P_(300) IN AGED PATIENTS WITH SCHIZOPHRENIA

目的:观察老年慢性精神分裂症(SCS)患者P300的变化。方法:共有40例正常老人和34例SCS患者,应用丹麦仪器及两种短音刺激,完成p30D检查。结果:部分SCS患者波形有切迹。Fz、Cz和Pz三记录点比较无差异。N1靶潜伏期在额区右侧延长于左侧。与正常老人比较;SCS患者靶潜伏期主成分(N1-P2-N2-P3)前移(P<0.01),靶波幅P2和P3降低(P<0.01)。非靶改变同靶刺激。结论:P300可以辅助评定SCS患者的认知功能状态。

Objective: To investigate the variations of auditory P3 of aged patients with schizophrenia. Methods: An 'oddball' paradigm was used to elicit the auditory P300from 34 aged patients diagnosed as schizophrenia and 40 age - matched normal control. The instrument used was a Dantec Concerto SEEG - 16. Results; Some patients presented a notch in their P300 waveform. No significant difference was found between the P300of schizophrenics at Fz, Cz and Pz. Within the patient group, a longer N1 latency was found at F4 than that at F3 . The schizophrenics showed reduced N1 - P2 - N2 - P3 latencies and decreased P2 and P3 amplitudes (p < 0.01) as compared to the normal control. Conclusion: The auditory P300 is of value in assessing cognitive dysfunction of schizophrenics.