细胞免疫功能检测在腹腔热化疗治疗癌性腹水中的临床意义

Clinical significance of cellular immunity examination in intraperitoneal heat-chemotherapy for malignant ascites

目的 探讨腹腔热化疗治疗癌性腹水患者细胞免疫功能的变化及其临床意义。方法 将 76例癌性腹水患者随机分为腹腔热化疗组和腹腔化疗组 ,每组 38例 ,化疗方案为FP方案。检测患者外周静脉血的T细胞亚群 (CD3+ 、CD4 + 、CD8+ 和CD4 + /CD8+ )和NK细胞 (CD16 + 5 6 + )值。结果 腹腔热化疗组治疗后的外周血T细胞CD3+ 、CD4 + 、CD4 + /CD8+ 比值和NK细胞数较治疗前明显上升 (P <0 .0 0 1) ,而腹腔化疗组治疗前后外周血的T细胞CD3+ 、CD4 + 、CD4 + /CD8+ 比值和NK细胞数无明显变化 (P >0 .0 5 )。结论 腹腔热化疗可以改善患者机体的细胞免疫功能 ,腹腔化疗和热疗联合使用可明显提高癌性腹水的治疗效果。

Objective To investigate the changes in c ellular immunity and its clinical significance in intraperitoneal heat-chemoth erapy for treatment of malignant ascites.Methods Seventy-six patients with malignant ascites were randomized into two groups: intraperitoneal heat-chemotherapy grou p of 38 patients, and intraperitoneal chemotherapy group of 38 patients. Chemoth erapy regimen was FP regimen.T lymphocyte subsets (CD3+,CD4+,CD8+ and CD 4+/CD8 +) and NK cells(CD16+56+) in peripheral blood were examined. Results T lymphocyte subsets CD3+,CD4+ and CD4+/CD8 + and NK cells(CD16+56+)were significantly higher after intraperitoneal h e at-chemotherapy than those before(P<0.001).T lymphocyte subsets CD3+、CD4 + and CD4+/CD8+ and NK cells(CD16+56+)had no significant change after intraperitoneal chemotherapy as compared with those before(P>0.05). Conclusi ons Intraperitoneal heat-chemotherapy can improve the cellul ar immunity and therapeutic effectiveness for the patient with malignant ascites .