血管紧张素Ⅱ1型受体自身抗体与子痫前期

Association between Autoantibodies against Angiotension Ⅱ Type 1 Receptor and Pre-Eclampsia (Review)

子痫前期以高血压、蛋白尿为特征,并伴有全身多脏器的损害。其发病率为3%~5%,是母婴发病率及死亡率较高的主要原因。重症患者只有及时终止妊娠才可阻止孕妇和胎儿情况的进一步恶化。目前子痫前期的发病机制尚未研究清楚。近来,多项研究证实子痫前期孕妇血清中存在抗血管紧张素Ⅱ1型受体自身抗体,通过专一识别细胞外第二环功能表位肽段发挥作用。本文旨在综述这些最新进展。

Pre-eclampsia is a serious hypertensive disorder of pregnancy that affects 3% - 5% of pregnancies, and remains the leading cause of maternal and neonatal mortalities and morbidities in the world. It is a multisystemic disease with the common features of hypertension and proteinuria. In serious cases, termination of pregnancy is the only available option to prevent further deterioration of the fetus and mother. To date, the factors triggering, and the underlying mechanisms, responsible for the pathogenesis of pre-eclampsia remain unknown. Recently, numerous studies have shown that pre-eclamptic women possess autoantibody against angiotensin Ⅱ type 1 receptor, which bind to and activate the receptor provoking biological responses relevant to the pathogenesis of pre-eclampsia. The current paper is to review the most recent development.