成骨分化相关信号通路的研究进展

Research Progress of Osteogenesis-Related Signaling Pathways

目的:成骨分化是骨质形成的基础,也是骨代谢的关键步骤。近年来,关于成骨分化的分子机制,国内外取得了许多突破性的进展。故围绕成骨分化相关信号通路研究进展这一要点进行综述和分析。方法:检索近几年国内外成骨分化及成骨相关信号通路研究的文献,并作总结分析。结果:发现多条信号通路参与成骨分化,其中,BMP-SMAD、Wnt/β-Catenin、Notch、Hedgehog、MAPK、FGF信号通路在成骨分化过程中最为关键。多条信号通路间存在着相互作用,构成了一个复杂的调控网络,但由于研究手段的局限,成骨分化相关信号通路的具体作用机制仍不明了。结论:若能说明这些信号通路各自发挥作用的机制及各条通路之间的相互关系,对阐明成骨分化的具体机制具有重要意义。

Objective: Osteogenesis is the foundation of bone formation and key procedure of bone metabolism. In recent years, major progress was made in the molecular mechanism of osteogenesis at home and abroad. Therefore, the mechanism and research progress of osteogenesis-related signaling pathways was reviewed. Methods: Literature about ossification and osteogenesis-relate signaling pathways in recent years were reviewed and analyzed. Results: Several signaling pathways have been found osteogenesis-related, among them, BMP-SMAD, Wnt/β-Catenin, Notch, Hedgehog, MAPK and FGF signaling pathways play the leading role in bone-formation. Besides, a complex regulatory network is composed of interactions between multiple signaling pathways. However, the specific mechanism of osteogenesis-related signaling pathways is still unclear because of limited research methods. Conclusion: To make clear the mechanism of these signaling pathways respectively and their interactions is of great significance for illustrating the complete mechanism of osteogenesis.