帕瑞昔布在脊柱术后镇痛疗效的Meta分析

Meta-Analysis of Outcomes of Parecoxib in the Postoperative Analgesia for Spinal Surgery

目的:系统评价帕瑞昔布在脊柱术后镇痛治疗的有效性。方法:计算机检索PubMed、Science Direct Online、Springer、CNKI、万方和维普,搜集有关帕瑞昔布在脊柱术后镇痛的随机对照试验(RCT)。由两位研究者按照纳入与排除标准筛选文献、提取资料和评价质量后,采用RevMan5.0软件进行Meta分析。结果:共纳入12个RCT,共636例患者。Meta分析结果显示:术后2、6、12、24、48 h,帕瑞昔布与安慰剂相比较,VAS评分具有明显的异质性(P <0.05),效果差异有统计学意义。结论:帕瑞昔布在脊柱术后镇痛可以达到满意的镇痛效果,可作为脊柱术后常规镇痛治疗。

Objective: To make a Meta-analysis of outcomes of parecoxib in the postoperative analgesia for spinal surgery. Methods: By searching PubMed, Science Direct Online, Springer and CNKI, etc., the published articles about studies of outcomes of parecoxib in the postoperative analgesia for spinal surgery were collected. Review Manager 5.1 software was used for data analysis. Results: Twelve randomized controlled trials studies including 636 patients were included in the Meta-analysis. Results of Meta-analysis show, VAS 2 h, 6 h, 12 h, 24 h, 48 h had significant difference between two groups. Conclusion: The parecoxib in the postoperative analgesia for spinal surgery has better effect than the placebo. The parecoxib can be used for a better analgesia for spinal surgery as usual.