老年骨质疏松与维生素D研究进展

A Review of Osteoporosis and Vitamin D in the Elderly

随着我国人口老龄化的家中,老年人特有疾病的发病率呈上升趋势。其中一种疾病是骨质疏松症。骨质疏松症的真正发病率是未知的,但是估计表明,这种疾病影响着很大比例的人口,骨折是骨疏松最严重的后果之一,特别是在老年人群中。髋部骨折可能是毁灭性的,这对医疗保健系统造成了重大负担,因此可以预防或治疗这种疾病的干预措施成为临床研究的重点。维生素D是骨骼健康的重要组成部分,已在临床研究中作为治疗骨质疏松症的药物进行了测试。尽管取得了进展,但仍有一些关于维生素D的目标血液水平,补充该维生素的最有效方式以及该补充剂在老年人中的临床效果的一些争论。在本综述中,我们将重点介绍维生素D的代谢和维生素D与老年骨质疏松的关系。

With the increase of the average age of our population, the incidence of diseases specific for older adults has been increasing. One of such diseases is osteoporosis. The actual incidence of osteopo-rosis is unknown. But the estimates suggest that this disease affects wide proportion of the popu-lation and that fractures are one of the most serious consequences of osteoporosis, especially in the elderly population. Hip fractures can be devastating, which places a significant burden on the healthcare system. So interventions that can prevent or treat the disease have become the focus of clinical research. Vitamin D is an important component of bone health and has been tested in clin-ical studies as a drug for the treatment of osteoporosis. Despite advances, there are still some de-bates about the target blood levels of vitamin D, the most effective way to supplement the vitamins, and the clinical effects of the supplements in the elderly. In this review, we will focus on the me-tabolism of vitamin D and the relationship between vitamin D and senile osteoporosis.