山奈酚诱导雌激素相关受体抑制肿瘤生长的分子机制研究进展

Advances in Molecular Mechanisms of Estrogen-Associated Receptors Induced by Kaempferol in Inhibiting Tumor Growth

中药活性成分抗肿瘤目前成了抗肿瘤新治疗方法探索的热点。大量研究表明黄酮类化合物在抑制肿瘤细胞生长过程中具有促进ROS释放、促进细胞凋亡、调节免疫活性等作用。中药提取物山奈酚是黄酮类化合物。目前许多研究发现,山奈酚有抗肿瘤作用,其机制主要包括以下几种:诱导细胞凋亡,调节细胞周期,抑制新生血管生成,抑制肿瘤转移,氧化与促氧化作用,抗炎等。近些年来的研究发现山奈酚可以通过调节雌激素相关受体发挥其抗肿瘤作用。

Anti tumor activity of active ingredients of traditional Chinese medicine has become a hot spot of new anti-cancer therapy. A great number of studies have proved that flavonoids can promote the release of ROS, promote cell apoptosis and regulate immune activity in the process of inhibiting tumor cell growth. Kaempferol, Chinese herbal extract, is a flavonoid compound. At present, many studies have found that kaempferol has anti-tumor effect, which mechanisms include inducing apoptosis, regulating cell cycle, inhibiting angiogenesis, inhibiting tumor metastasis, oxidizing and promoting oxidation, anti-inflammation and so on. Recent studies have found that kaempferol can play an antitumor role by regulating estrogen-associated receptors.