Sirt3在褪黑素减少线粒体损伤的研究进展

Progress of Melatonin in Reducing Mitochondrial Injury by Interacting with Sirt3

背景:褪黑激素是一种起源于松果腺的特殊吲哚胺,具有抗氧化,抗衰老和调控代谢的特性,近年来,与褪黑激素在细胞中作用的相关研究逐渐集中于线粒体。在线粒体中,褪黑激素可以刺激沉默信息调控蛋白3 (Sirt3)活性,通过加强其去乙酰化作用调控Foxo3a、SOD2及TCA周期中大部分代谢酶的活性,进而在心血管疾病、肝肾损伤、重金属危害等疾病中发挥保护作用。目的:对褪黑激素与Sirt3相互作用减少线粒体损伤的相关文献进行综述。内容:整理和阐述了褪黑激素与Sirt3在线粒体的表达、转移、共定位,及对不同器官的保护作用机制。趋向:褪黑激素与Sirt3在线粒体内共享多种信号通路,两者的相互作用可能是未来一个富有成效的研究领域。

Background: Melatonin is a special indole amine derived from the pineal gland, with multiple properties of antioxidant, anti-aging and metabolic. Recent years, studies related to the role of melatonin in cells have gradually focused on mitochondria. In mitochondria, melatonin stimulates Sirt3 activity. It regulates the activity of Foxo3a, SOD2 and the most metabolic enzymes in TCA cy-cles by strengthening the deacetylation effect of Sirt3, and thus plays a protective role in diseases such as cardiovascular disease, liver and kidney injury, and heavy metal hazards. Objective: To re-view the related literatures on the interaction between melatonin and Sirt3 in reducing mito-chondria injury. Content: Based on series studies, this article illuminated the expression, metastasis and co-localization of melatonin and Sirt3 in mitochondria, and summarized the protective mechanism of melatonin in multiple organs. Trend: The interaction between Melatonin and Sirt3 will be one of the most valuable research field in mitochondria protection with both shared multiple signal pathways.