多重打击学说下的IgAN基因多态性的研究进展

Advances in Research on IgAN Gene Polymorphism under Multiple-Hits Theory

IgA肾病(IgA nephropathy, IgAN)是全世界最常见的原发性肾小球疾病。遗传,免疫,糖基化改变等多重打击导致系膜区IgA1及其免疫复合物沉积,造成系膜细胞的增殖及肾损伤。临床表现多样并多伴有血尿,部分进展为终末期肾脏病。目前,IgAN的发病机制尚不清楚。随着全基因组连锁分析(GWAS)在IgAN的不断应用,遗传因素的致病作用受到越来越多的关注。本文将对GWAS发现的基因及这些基因在多重打击学说下的研究进展加以综述。

IgA nephropathy(IgAN)is the most common primary glomerulonephritis in the world.Multiple hits such as heredity,immunity and glycosylated changes lead to deposition of IgA1 and its immune complexes in the mesangial area,and result in mesangial cell proliferation and glomerular damage.The clinical manifestations are diverse and often accompanied by hematuria,and some progress to end-stage renal disease.At present,the pathogenesis of IgAN is still unclear.With the continuous application of genome-wide linkage analysis(GWAS)in IgAN,the pathogenic role of genetic factors has received more and more attention.This article will review the genes discovered by GWAS and the research progress of these genes under the multiple-hits theory.