幽门螺杆菌感染与代谢综合征的相关性研究

The Correlation between Helicobacter pylori Infection and Metabolic Syndrome

幽门螺杆菌(HP)是一种能够长期定植于胃黏膜的革兰阴性杆菌。HP感染可导致慢性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤,近几年的研究显示HP感染与肠道外的疾病也有一定的相关性。代谢综合征(MS)是以腹型肥胖、脂代谢异常、高血压、糖尿病、高尿酸血症等合并症为特点的一组临床症候群,以多种物质代谢异常为基础的病理生理改变,存在多个致动脉粥样硬化危险因素,最终导致心脑血管疾病的发生和发展。近些年来,越来越多的研究显示出HP感染与MS之间有一定的相关性。

Helicobacter pylori(HP)is a Gram-negative bacillus that can colonize the gastric mucosa for a long time.HP infection can lead to chronic gastritis,peptic ulcer,gastric cancer and gastric muco-sa-associated lymphoid tissue lymphoma.In recent years,studies have shown that HP infection is also associated with extraintestinal diseases.Metabolic syndrome(MS)is a group of clinical syn-dromes characterized by abdominal obesity,abnormal lipid metabolism,hypertension,diabetes,hyperuricemia and other comorbidities.Pathophysiological changes based on abnormal metabo-lism of various substances exist.Multiple risk factors for atherosclerosis ultimately lead to the development and progression of cardiovascular and cerebrovascular diseases.In recent years,more and more studies have shown a certain correlation between Hp infection and MS.