前列腺癌特异性膜抗原用于前列腺癌的诊断与治疗研究进展

Progress in the Diagnosis and Treatment of Prostate Cancer Specific Membrane Antigen for Prostate Cancer

前列腺特异性膜抗原(Prostate specific membrane, PSMA)是具有叶酸水解酶和羧肽酶的2型整合膜糖蛋白,具有较高的前列腺组织特异性,其在低分化及转移性前列腺癌中呈现高表达,与前列腺肿瘤恶性程度正相关,基于此,以PSMA为靶标检查及治疗前列腺癌的影像学方式不断发展。该文章目的在于回顾PSMA作为前列腺癌影像学诊断和治疗标志物的研究进展。

Prostate specific membrane(PSMA)is a type 2 integral membrane glycoprotein with folate hy-drolase and carboxypeptidase,which has high prostate tissue specificity and is high in poorly dif-ferentiated and metastatic prostate cancer.The expression is positively correlated with the degree of malignancy of prostate tumors.Based on this,the imaging method for detecting and treating prostate cancer with PSMA is continuously developed.The aim of this article is to review the progress of PSMA as a marker for imaging diagnosis and treatment of prostate cancer.