GABAA受体效应与新生儿癫癎治疗

The Effect of GABAA Receptor and Its Treatment of Neonatal Epilepsy

近年来的研究显示苯巴比妥类等针对性作用于GABAA受体的药物在新生儿癫癎治疗中的临床疗效不佳,且可能导致进一步的远期脑损害,原因在于新生脑中GABAA受体表现为兴奋性效应,随着神经系统发育而逐渐转化为成熟脑中的重要抑制性受体。位于神经元细胞膜上的转运蛋白NKCC1、KCC2及L型Ca2+通道共同参与了新生期GABAA受体激活后兴奋性效应的形成。

The drug phenobarbital which acts as GABAA receptor modulator is recently found to have a poor clinical outcome and even a long-term injury to brain.The reason may lie on the excitatory effect of GABAA receptor in developing brain rather than the inhibitory effect in developed brain.Trans-porter NKCC1 and KCC2 along with L-type Ca2+channel take part in the generation of the excitatory effect,which indicates a new way of target therapy of neonatal epilepsy.