非酒精性脂肪肝相关慢性肾病发病机制进展

Progress in the Study of the Pathogenesis of Chronic Kidney Disease Associated with Nonalcoholic Fatty Liver Disease

随着肥胖和2型糖尿病(Type 2 Diabetes Mellitus, T2DM)发病率的上升,非酒精性脂肪肝(Non-alcoholic Fatty Liver Disease, NAFLD)已经成为全球最常见的慢性肝病。NAFLD是一种多系统疾病,与代谢综合征、心血管疾病,慢性肾脏病密切关联。近年来,慢性肾脏病(Chronic Kidney Disease, CKD)患病率逐年上升,已成为全球性的公共卫生问题,严重威胁人体健康。很多研究表明,NAFLD与肾功能受损相关。肾脏损伤的早期表现为足细胞损伤和蛋白尿。因此,NAFLD与CKD逐渐成为学者们关注的热点。我们推测NAFLD与CKD之间存在共同发病机制。本文目的在于对非酒精性脂肪肝推测相关慢性肾病发病机制进行综述。

With the increase of obesity and Type 2 Diabetes Mellitus(T2DM),non-alcoholic Fatty Liver Disease(NAFLD)has become the most common chronic Liver Disease in the world.NAFLD is a multisystem disease closely associated with metabolic syndrome,cardiovascular disease and chronic kidney disease.In recent years,the prevalence of chronic kidney disease(CKD)increases year by year,which has become a global public health problem and a serious threat to human health.Many studies have shown that NAFLD is associated with impaired renal function.The early manifestations of kidney injury are podocyte injury and proteinuria.Therefore,NAFLD and CKD have gradually become the focus of attention of scholars.We speculate that there is a common pathogenesis between NAFLD and CKD.The purpose of this article is to summarize the pathogenesis of CKD associated with NAFLD.