阻塞性睡眠呼吸暂停与癌症

Obstructive Sleep Apnea and Cancer

阻塞性睡眠呼吸暂停(OSA)可能影响癌症的发生、发展,增加癌症死亡率。本文综述了近年来关于OSA的动物实验和流行病学研究,发现OSA与癌症密切相关。动物实验揭示间歇性缺氧和睡眠片段化通过改变肿瘤生物学参与癌症的发生和进展;流行病学研究表明OSA增加癌症的发病率与病死率。本文旨在为临床医生对癌症危险因素筛查提供新视角,同时为OSA合并癌症患者的诊治提供新的理论依据。

Obstructive sleep apnea (OSA) may affect the occurrence and development of tumors and increase cancer mortality. In this review, the animal experiments and the epidemiological data show that OSA is closely related to cancer. The animal experiments indicate that intermittent hypoxia and sleep fragmentation have effects on cancer biology and are likely contributing to tumor progression. The epidemiological evidences indicate that OSA may conduce to increased cancer incidence and mortality. This paper aims to provide a new perspective for clinicians to screen for tumor risk factors and a new reference for the diagnosis and treatment of OSA patients with cancer.