脑小血管病与轻型卒中后认知障碍的关系

The Relationship between Cerebral Small Vessel Disease and Cognitive Impairment after Minor Stroke

目的:探究脑小血管病(Cerebral Small Vessel Disease, CSVD)对轻型卒中后认知障碍的影响。方法:收集2017年10月到2019年9月期间在青岛大学附属医院神经内科就诊的轻型卒中患者,进行CSVD评分及认知障碍评分,将发病3个月的患者分为认知障碍组和非认知障碍组,采用logistic回归分析筛选发病3个月时认知功能障碍的独立危险因素。结果:多因素logistic回归分析显示,教育年限、PVS数量、脑白质高信号Fazekas评分、CSVD总体负担是轻型卒中后3个月认知障碍的独立危险因素。结论:综上所述,教育年限、PVS数量、WMH Fazekas评分、CSVD总体负担是轻型卒中后3个月认知障碍的独立危险因素。

Objective: To investigate the effects of cerebral small vessel disease (CSVD) on cognitive impairment after minor stroke. Methods: The patients with minor stroke were collected from October 2017 to September 2019 in the Department of Neurology, affiliated Hospital of Qingdao University, and the CSVD score and cognitive impairment score were carried out. The patients were divided into cognitive impairment group and non-cognitive impairment group. Logistic regression analysis was used to screen the independent risk factors of cognitive impairment in 3 months after onset. Results: Multivariate logistic regression analysis showed that years of education, number of PVS, WMH Fazekas scores, and the total burden of CSVD were independent risk factors for cognitive impairment in 3 months after minor stroke. Conclusions: Years of education, number of PVS, WMH Fazekas scores and the total burden of CSVD are independent risk factors for cognitive impairment after minor stroke.