慢性阻塞性肺疾病与呼吸道微生态的关系研究进展

Research Progress on the Relationship between Chronic Obstructive Pulmonary Disease and Respiratory Microecology

近年来关于慢性阻塞性肺疾病与呼吸道微生态的研究引起了大众的关注,人们通过不同的方法,如培养法、涂片法及近年的PCR法等对COPD不同病程中的微生物进行研究发现:① 金黄色葡萄球菌、卡他莫拉菌、肺炎克雷伯杆菌在COPD的病程中起到推动作用;② 激素的使用会影响COPD呼吸道的微生态,进而影响治疗;③ AECOPD中最常见的病毒为鼻病毒,其次为流感病毒,呼吸道合胞病毒也占一定比例;④ 增强免疫力的药物可能会对COPD患者病情缓解及减少急性加重带来获益。

In recent years, research on chronic obstructive pulmonary disease and respiratory tract microecology has aroused public attention. People have used different methods, such as the culture method, smear method, and PCR method in recent years, to study the microorganisms in different courses of COPD and find that: ① Staphylococcus aureus, Moraxella catarrhalis, and Klebsiella pneumoniae play a driving role in the course of COPD;② The use of hormones will affect the microecology of COPD respiratory tract, and then affect treatment;③ The most common virus in AECOPD is Nasal Viruses, followed by Influenza viruses, and Respiratory syncytial viruses also account for a certain proportion;④ Drugs that enhance immunity may benefit patients with COPD and reduce their acute exacerbations.