摘要
目的:探讨缺血性脑血管病(Ischemic cerebrovascular disease, ICD)患者血清胱抑素C (Cystatin C, CysC)与颈动脉斑块性质及颈动脉狭窄程度的关系。方法:选取完善头颈部CT血管造影(CTA)的ICD患者128例,采用全自动生化分析仪测定其CysC水平。根据研究对象的血清CysC中位数水平将研究对象分为低CysC组(n = 66,CysC浓度≤0.95 mg/L)和高CysC组(n = 62,CysC浓度】0.95 mg/L),然后比较两组患者的颈动脉斑块性质和颈动脉狭窄程度。使用Spearman等级相关分析血清CysC水平与ICD患者颈动脉斑块性质和颈动脉狭窄程度的相关性。结果:高CysC组钙化斑块的比例较低CysC组低(χ2 = 18.636, P 2 = 7.326, P2 = 11.291, P 2 = 3.185, P 】0.05)。高CysC组轻度狭窄比例较低CysC组低(χ2 = 20.243, P 2 = 7.212, P 2 = 7.819, P 2 = 1.671, P 】0.05)。Spearman等级相关分析显示,ICD患者颈动脉斑块稳定程度、颈动脉狭窄程度均与血清CysC呈正相关(r = 0.450, P 【0.05;r = 0.376, P 【0.05)。结论:ICD患者颈动脉斑块性质、颈动脉狭窄程度与血清CysC水平相关。高CysC水平会增加不稳定斑块发生率,加重颈动脉狭窄程度。
Objective: To investigate the relationship between serum cystatin C (CysC) and the property of carotid plaque and the degree of carotid stenosis in patients with ischemic cerebrovascular disease (ICD). Methods: 128 patients with ICD who had completed CT angiography (CTA) of head and neck were selected and their CysC levels were measured by automatic biochemical analyzer. The subjects were divided into low CysC group (n = 66, CysC concentration ≤ 0.95 mg/L) and high CysC group (n = 62, CysC concentration >0.95 mg/L) according to the median level of serum CysC of the subjects. Then the property of carotid plaque and the degree of carotid stenosis were compared between the two groups. Spearman grade correlation was used to analyze the correlation between serum CysC level and carotid stenosis and plaque property in ICD patients. Results: The proportion of calcified plaque in high CysC group was lower than that in low CysC group (χ2 = 18.636, P χ2 = 7.326, P χ2 = 11.291, P χ2 = 3.185, P >0.05). The proportion of mild stenosis in high CysC group was lower than that in low CysC group (χ2 = 20.243, Pχ2 = 7.212, P χ2 = 7.819, Pχ2 = 1.671, P >0.05). Spearman grade correlation analysis showed that the degree of carotid plaque stability and carotid stenosis in ICD patients were positively correlated with serum CysC (r = 0.450, P
出处
《临床医学进展》
2020年第6期1049-1055,共7页
Advances in Clinical Medicine
