九头狮子草治疗霉菌性阴道炎有效部位的筛选研究

Study on the Active Parts of Peristrophe japonica (Thunb.) Bremek of Colpomycosis Treatment Effect

目的:筛选九头狮子草治疗小鼠霉菌性阴道炎的有效部位。方法:采用白色念珠菌悬液注入小鼠阴道建立小鼠霉菌性阴道炎动物模型,观察九头狮子草不同溶剂提取的各极性部位对小鼠霉菌性阴道炎的治疗作用。结果:九头狮子草水提液、石油醚提取部位和70%乙醇提取部位对病原菌转阴率和阴道黏膜炎症的治愈程度均有明显提高,其中,水提液组、石油醚提取部位组和70%乙醇提取部位组对白色念珠菌的转阴率分别为90%,80%,70%。结论:九头狮子草石油醚提取部位和70%乙醇提取部位为其治疗霉菌性阴道炎的有效部位。

Objective: To study the active parts of Peristrophe japonica of colpomycosis treatment effect. Methods: The colpomycosis model was established by injecting the blastomyces albicans into the vagina of the mice and the treatment effect of each extract of Peristrophe japonica was observed. Results: The results showed three drug administration groups (including water extract of Peristrophe japonica, ligarine fraction and water fraction) showed marked treatment effect on the vaginitis models. The effect of water extract of Peristrophe japonica group was stronger than that of the ligarine fraction and water fraction groups. The pathogens seroconversion rates in blastomyces albicans were orderly as follows: 90%, 80%, 70%. Conclusion: The ligarine fraction and water fraction of Peristrophe japonica might be the active extracts of curing colpomycosis.