血清胱抑素C对肾脏病诊断的价值

The Value of Serum Cystatin C in the Diagnosis of Renal Diseases

血清胱抑素C (CysC)是一种细胞外抑制素,在体液中丰富的表达,可能对间质半胱氨酸蛋白酶有抑制作用。分子量较小,产生率恒定,可以调控细胞内外的蛋白水解,并且可经肾小球过滤,在近曲小管重吸收和代谢,肾脏是将其清除的唯一器官,同时,它不受性别、年龄、饮食等因素影响。血清胱抑素C (CysC)测定是测定肾脏病患者肾功能的一种简单实用的方法。最近的研究表明,CysC在预测肾损害的早期阶段具有更好的诊断准确性或至少相当于肌酐,并且与透析患者的临床结果密切相关。因此,胱抑素C在肾脏疾病、肿瘤、糖尿病、肝硬化、心脏病的诊断中有一定价值,本文对血清胱抑素C在肾脏病诊断中的价值作一论述。

Serum cystatin C (CysC) is a kind of extracellular inhibin, which is abundant in body fluid and may inhibit interstitial cysteine protease. The molecular weight is small, the production rate is constant, it can regulate the protein hydrolysis inside and outside the cell, and it can be filtered by the glomerulus and reabsorbed and metabolized in the proximal convoluted tubule. The kidney is the only organ to remove it, and at the same time, it is not affected by sex, age, diet and other factors. The determination of serum cystatin C (CysC) is a simple and practical method to measure the renal function of patients with renal disease. Recent studies have shown that CysC is more accurate or at least equivalent to creatinine in predicting the early stage of renal damage and is closely related to the clinical outcome of dialysis patients. Therefore, cystatin C has certain value in the diagnosis of kidney disease, tumor, diabetes, liver cirrhosis and heart disease. This paper discusses the value of serum cystatin C in the diagnosis of kidney disease.