阿尔茨海默病的临床研究进展

Clinical Research Progress of Alzheimer’s Disease

阿尔茨海默病(Alzheimer’s disease, AD)是一种进行性,不可逆转,无法治愈的神经退行性疾病,是痴呆最常见的一种。患者主要症状是认知功能持续降低,功能性自立丧失,行为改变,需要人员护理。在我国,由于患者和家属对本病认识的局限,70%的患者确诊时已为重度,错过了最佳干预和治疗时机,到目前为止,还没有一种能够预防或减缓疾病进展的药物。老年痴呆也被称为“无声威胁”,正成为最昂贵的疾病之一,本文对AD的临床研究进展作一综述。

Alzheimer’s disease is a progressive, irreversible, incurable, neurodegenerative illness and the most common of the dementing disorders. Slow decline caused by this disease, is characterized by cognitive deterioration, loss of functional independence, changes in behaviour, and expanding needs for care. In our country, due to the limitation of patients’ and their families’ understanding of the disease, 70% of the patients have been diagnosed as severe and missed the best opportunity for intervention and treatment. AD is becoming one of the most problematic and expensive illnesses for the civilization, also known as “silent threat”. This paper has summarized these research achievements of AD.