胃癌患者CD163表达与HER-2表达情况的相关性分析

Correlation Analysis of CD163 Expression and HER-2 Expression in Patients with Gastric Cancer

目的:探讨M2型肿瘤相关巨噬细胞特异性受体CD163的表达与HER-2基因及预后的相关性分析。方法:随机选择在2013年1月至2019年12月在青岛大学附属医院接受胃癌手术的60例患者。采用免疫组织化学法检测胃癌组织肿瘤相关巨噬细胞标记物的表达情况,采用χ2检验分析CD163表达与临床病理学参数之间的关系。采用Kaplan-Meier生存分析法分析CD163与预后的关系。结果:CD163+肿瘤相关巨噬细胞与肿瘤生物学行为,即TNM分期(P = 0.017)、淋巴结转移(P = 0.009)呈现明显相关,差别有统计学意义,与HER-2表达水平无显著性差异。CD163+肿瘤相关巨噬细胞与胃腺癌患者术后总生存时间,差别无统计学意义。结论:M2型肿瘤相关巨噬细胞特异性受体CD163的表达与TNM分期、淋巴结转移有关,CD163的表达与HER-2基因之间差异无统计学意义。CD163的表达与胃腺癌患者术后总生存时间差别无统计学意义。

Objective: To investigate the correlation analysis between the expression of M2 tumor-associated macrophage specific receptor CD163 and HER-2 gene and prognosis. Methods: Sixty patients who underwent gastric cancer surgery in Qingdao University Hospital from January 2013 to December 2019 were randomly selected. Immunohistochemistry was used to detect the expression of tumor-related macrophage markers in gastric cancer tissues, and the χ2 test was used to analyze the relationship between CD163 expression and clinicopathological parameters. Kaplan-Meier survival analysis method was used to analyze the relationship between CD163 and prognosis. Results: CD163+ tumor-associated macrophages are related to TNM staging (P = 0.017) and lymph node metastasis (P = 0.009), but there is no significant difference in the expression of HER-2. There was no significant difference in overall survival time between CD163+ tumor-associated macrophages and gastric adenocarcinoma patients. Conclusion: The expression of M2 tumor-associated macrophage specific receptor CD163 is related to TNM staging and lymph node metastasis, and there is no significant difference between the expression of CD163 and HER-2 gene. There was no significant difference between the expression of CD163 and the overall survival time of patients with gastric adenocarcinoma.