CD40-CD40L信号通路与急性冠脉综合征相关性研究进展

Research Progress on Relationship between CD40-CD40L Signal Pathway and Acute Coronary Syndrome

CD40及其免疫调节配体CD40L是一对互补跨膜糖蛋白,分别属于神经生长因子受体(NGFR)/肿瘤坏死因子受体(TNF-R)超家族和肿瘤坏死因子(TNF)超家族成员,参与许多疾病的发生发展过程。研究发现,CD40-CD40L通路不仅与免疫性疾病(自身免疫性疾病和免疫缺陷病)的发展进程密切相关,同时还介导炎症反应,几乎贯穿急性冠状动脉综合征(acute coronary syndrome, ACS)全过程。现就CD40-CD40L通路与急性冠脉综合征的相关性做一简要概述,以期进一步为探讨CD40-CD40L通路与心血管疾病的预防、治疗提供理论依据。

CD40 and its immunoregulatory ligand (CD40L) are a pair of complementary transmembrane glycoproteins belonging to the nerve growth factor receptor (NGFR)/tumor necrosis factor receptor (TNF-R) superfamily and tumor necrosis factor (TNF) superfamily respectively and participate in the occurrence and development of many diseases. It has been found that CD40-CD40L signal pathway is not only closely related to the development of immune diseases (autoimmune and immune deficiency diseases), but also mediates inflammatory response, almost throughout the whole process of acute coronary syndrome (ACS). In this paper, the interactions between CD40- CD40L pathway and acute coronary syndrome were briefly summarized, to provide more theoretical basis for CD40-CD40L signal pathway and prevention and treatment of cardiovascular diseases.