中老年睡眠障碍与认知功能相关性分析

Analysis of Correlation between Sleep Disorder and Cognitive Function in the Middle and the Old

目的:研究具有睡眠障碍人群其认知功能的改变。方法:在青岛社区选取教育程度为小学及以上50~80岁人群,共327名参与者完成匹兹堡睡眠质量指数(Pittsburgh sleep quality index, PSQI)测试,按照PSQI测试总分 】7分认定为睡眠障碍作为筛查标准进行分组,分睡眠良好组(PSQI 0.05)。表示注意功能的SDMT得分与PSQI总分、入睡时间、睡眠效率呈负相关,相关性显著;表示执行功能的Stroop得分与PSQI总分呈正相关;性别与PSQI总分、主观睡眠质量、入睡时间、睡眠时间呈正相关,相关性显著;年龄与睡眠效率、催眠药物呈正相关,相关性显著。结论:本研究显示,睡眠障碍主要影响注意及执行功能,调节睡眠障碍可有助于预防认知功能损伤。

Objective: To study the changes of cognitive function in people with sleep disorder. Methods: Right-handed people aged 50 - 80 years old with primary school education and above in Qingdao community were selected. A total of 327 participants completed PSQI, the groups were grouped according to the PSQI total score of >7 for the presence of sleep disorders as the screening criteria. Neuropsychological tests were carried out in five cognitive areas: episodic memory, attention and processing speed, visual-spatial ability, language ability and executive ability. Episodic memory tests were comprised of the Auditory Verbal Learning Test (AVLT) and Recall component of Rey Osterrieth Complex Figure Test (ROCF). Attention and processing speed tests were comprised of the Trail Making Test A (TMT-A) and Symbol Digit Modalities Test (SDMT). Visual-spatial tests were comprised of the Copy component of ROCF and Clock-Drawing Test (CDT). Language ability tests were comprised of the Boston Naming Test (BNT) and Verbal fluency. Executive function tests were comprised of the Trail Making Test B (TMT-B) and Stroop Color-word Test (Stroop). Results: In the two groups, attention and executive had significant differences (P 0.05). SDMT score of attention function was negatively correlated with PSQI total score, time to sleep and sleep efficiency, significant correlation. Gender was positively correlated with PSQI total score, subjective sleep quality, sleeping time, and sleeping time. Age was positively correlated with sleep efficiency and hypnotic drugs, and the correlation was significant. Conclusion: Sleep disorders mainly affect attention and executive function. Each factor of PSQI is related to different cognitive fields, which shows that sleep can be specifically regulated through changes in each cognitive field.