心力衰竭患者血清中Neuronostatin水平及其与心衰严重程度的关系

Serum Neurostatin Level in Patients with Heart Failure and Its Relationship with the Severity of Heart Failure

目的:观察心力衰竭患者血清中neuronostatin水平及其与心衰严重程度的关系,探讨其临床意义。方法:选择其中射血分数降低的62例心衰患者作为实验组,并选取同期非心衰患者72例为对照组,采用酶联免疫吸附试验(ELISA)测定血清中neuronostatin水平。结果:心衰组血清中neuronostatin的水平较非心衰组明显升高,差异有统计学意义(p 【0.05);心功能III级neuronostatin的水平明显高于II级,心功能IV级neuronostatin的水平明显高于II级,差异均有统计学意义(p 【0.05);经Spearman相关分析,心衰组NST的水平与不同心功能分级呈正相关(r = 0.649, p 【0.05);采用ROC曲线,neuronostatin诊断心力衰竭的AUC为0.944。结论:血清中NST的水平升高可能与心力衰竭的发生发展有关,且与心功能的分级呈正相关。

Objective: To observe the serum neuronostatin level in patients with heart failure and its relationship with the severity of heart failure, and to explore its clinical significance. Methods: 62 patients with heart failure with reduced ejection fraction were selected as the experimental group, and 72 patients with non-heart failure during the same period were selected as the control group. The level of neuronostatin in serum was determined by enzyme-linked immunosorbent assay (ELISA). Results: The level of neuronostatin in the serum of the heart failure group was significantly higher than that of the non-heart failure group, and the difference was statistically significant (p