期刊文献+

热毒宁、甘草酸苷联合治疗对第2期手足口病及其免疫细胞、炎性细胞因子的影响

Combination Therapy of Reduning and Glycyrrhizin for the Second Stage of Hand, Foot and Mouth Disease and Its Immune Cells, and Inflammatory Cytokines
下载PDF
导出
摘要 目的:探讨热毒宁、甘草酸苷联合治疗对第2期手足口病患儿的治疗效果、免疫细胞及炎性细胞因子的影响。方法:286例第2期手足口病患儿随机分成实验1组(66例)、实验2组(73例)、实验3组(72例)及实验4组(75例),同期63例健康体检儿童作为对照组。治疗5 d后,观察HFMD患儿的临床疗效。应用流式细胞术检测研究对象外周血T淋巴细胞、Th细胞、Tc细胞、NK细胞和B淋巴细胞所占淋巴细胞的百分比。酶联免疫吸附法测定炎性细胞因子IL-6、IL-10.、TNF-ɑ水平,分析各组间上述指标的差异。结果:1) 较实验1组,实验2组、实验3组及实验4组的退热时间、皮疹消退时间、精神状态恢复情况或惊颤消失时间及危重型病例转化率明显降低,治疗效率显著升高,差异有统计学意义(P 【0.05),实验4组的正常体温恢复时间、皮疹消退时间、精神状态恢复情况或惊颤消失时间明显高于实验2组及实验3组(P 【0.05);2) 第2期手足口病患儿T淋巴细胞、Th细胞、Th/Tc细胞比值较对照组显著降低,而B淋巴细胞百分比、IL-6、IL-10和TNF-ɑ水平明显升高,差异有统计学意义(P 【0.05);3) 较实验1组,实验2组、实验3组及实验4组的T淋巴细胞、Th细胞、Th/Tc比值显著升高,B淋巴细胞及IL-6、IL-10.、TNF-ɑ的水平明显降低(P皆 【0.05);且实验2组与实验4组的Th细胞、B淋巴细胞、Th/Tc比值、IL-6、IL-10.、TNF-ɑ间的差异有统计学意义(P 【0.05)。结论:较单用热毒宁,热毒宁及甘草酸苷联合治疗能显著地改善第2期手足口患儿的临床症状和免疫功能紊乱,但热毒宁联合甘草酸苷改善免疫功能的作用较单独用药是否有叠加作用需进一步研究。 Objective: To investigate the effect of Reduning combined with glycyrrhizin on immune cells and inflammatory cytokines in children with hand-foot-mouth disease (HFMD). Methods: 286 children with Stage II HFMD were randomly divided into the routine group (66 cases), the Reduning group (73 cases), the glycyrrhizin group (72 cases) and the combined group (75 cases), and 63 healthy children as the control group. After 5 days of treatment, the clinical therapeutic effect of HFMD children was observed. The percentage of T lymphocyte, Th cells, Tc cells, NK cells, and B lymphocyte in the lymphocyte of all subjects’ peripheral blood was measured by flow cytometry. Inflammatory cytokines IL-6, IL-10 and TNF-ɑ were measured by ELISA, to analyze the differences of the above indicators among the groups. Results: 1) Compared with the conventional treatment group, the time of antipyretic, the time of rash subside, the time of mental state recovery or the time of quiver subside and the conversion rate of critical cases were significantly decreased and the treatment efficiency was significantly increased (P
出处 《临床医学进展》 2021年第1期431-437,共7页 Advances in Clinical Medicine
  • 相关文献

参考文献5

二级参考文献46

  • 1杨华,周志才,奚峰.营养状况对慢性阻塞性肺疾病急性加重期严重程度及预后的评估[J].实用老年医学,2013,27(4):328-330. 被引量:7
  • 2张汝芝,朱文元,马佳,金慧玲,韩洪方.复方甘草酸苷对体外培养的角质形成细胞的作用[J].中国皮肤性病学杂志,2006,20(5):267-269. 被引量:8
  • 3Gulletta E, Bottoni U, Foti DP. Psoriasis, a new challenge forlaboratory medicine[J]. Clin Chem Lab Med, 2013, 51(7): 1363-1368.
  • 4Yang D, Zheng J, Zhang Y, et al. Total glucosides of paeony capsuleplus compound glycyrrhizin tablets for the treatment of severealopecia areata in children: a randomized controlled trial[J]. EvidBased Complement Alternat Med, 2013, 2013: 378219.
  • 5Kim HO, Kim JH, Chung BY, et al. Increased expression of the arylhydrocarbon receptor in patients with chronic inflammatory skindiseases[J]. Exp Dermatol, 2014, 23(4): 278-281.
  • 6Raut AS, Prabhu RH, Patravale VB. Psoriasis clinical implicationsand treatment: a review[J]. Crit Rev Ther Drug Carrier Syst, 2013,30(3): 183-216.
  • 7McCully ML, Ladell K, Hakobyan S, et al. Epidermis instructs skinhoming receptor expression in human T cells[J]. Blood, 2012,120(23): 4591-4598.
  • 8Chandran V. The genetics of psoriasis and psoriatic arthritis[J]. ClinRev Allergy Immunol, 2013, 44(2): 149-156.
  • 9Swindell WR, Johnston A, Voorhees JJ, et al. Dissecting the psoriasistranscriptome: inflammatory- and cytokine-driven gene expression inlesions from 163 patients[J]. BMC Genomics, 2013, 14: 527.
  • 10Ng TH, Britton GJ, Hill EV, et al. Regulation of adaptive immunity;the role of interleukin-10[J]. Front Immunol, 2013, 4: 129.

共引文献48

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部