细胞自噬参与调控牙周病发病机制的研究进展

Research Progress of Autophagy in the Mechanism of Periodontal Disease

牙周病原菌入侵宿主时可被细胞表面的模式识别受体识别,并进一步引起局部组织的炎症反应,介导牙周组织破坏并造成牙槽骨的吸收。细胞自噬作为一种广泛存在于真核细胞中的代谢机制,对维持细胞内环境稳定和抵御病原菌入侵和感染具有重要意义,在牙周病的发病机制中也扮演着重要角色。笔者就细胞自噬在牙周病原菌入侵、调控炎症分子机制、影响牙周软硬组织稳态等方面对其参与调控牙周炎发病机制的研究进展作一综述,为进一步探讨细胞自噬参与调控牙周炎发生发展的研究提供指导。

Periodontal pathogens could be recognized by various pattern recognition receptors when infecting host cells, inducing inflammatory response and mediating tissue damage as well as alveolar bone resorption. Meanwhile, autophagy is an intracellular homeostatic process responsible for clearance of damaged organelles and intracellular pathogens, which is also closely related to the mechanism of periodontal disease. This review summarizes the research progress of autophagy involved in regulating the pathogenesis of periodontitis in terms of periodontal pathogen invasion, regulation of inflammatory response, and influence on alveolar bone resorption, in order to provide further perspective for the future researches about the involvement of autophagy in the development of periodontitis.