高原地区红细胞与血尿酸浓度变化的研究进展

Research Progress on Changes of Red Blood Cell and Blood Uric Acid Concentration in Plateau Area

高海拔地区空气稀薄,氧分压低,为了适应高原地区的环境,机体的红细胞计数、血红蛋白浓度、血清尿酸水平会发生一系列的变化。长期慢性缺氧的特殊环境下,高原地区人群血清尿酸盐水平普遍增高,给高原人群的健康带来巨大的危害。本文将对高原地区红细胞增多与血尿酸浓度变化进行综述,进一步了解高原缺氧环境下红细胞增多引起尿酸升高的原因。为高原地区早发现、早诊断、早预防高尿酸血症提供依据。提高高原地区的临床医生及患者对尿酸指标升高的认识,对于高原地区血尿酸升高患者尽早采取预防和干预措施,有效改善高原地区患者的预后,提高生活质量。

In order to adapt to the plateau environment, the red blood cell count, hemoglobin concentration and serum uric acid level will have a series of changes. Under the special environment of chronic hypoxia for a long time, the level of serum uric acid in people at high altitude is generally increased, which brings great harm to the health of people at high altitude. In this paper, we will review the relationship between polycythemia and the change of serum uric acid concentration at high altitude, so as to further understand the causes of the increase of uric acid caused by polycythemia at high altitude to provide basis for early detection, early diagnosis and early prevention of hyperuricemia in plateau area. In order to improve the prognosis and quality of life of patients at high altitude, it is necessary to improve the awareness of clinicians and patients on the increase of uric acid index, and take preventive and intervention measures as soon as possible.