FAS/FAS-L蛋白及BCL2蛋白在卵巢癌中的研究进展

Research Progress of Fas/Fas-L Protein and BCL2 Protein in Ovarian Cancer

凋亡信号通路包括外源性凋亡途径及内源性凋亡途径。Fas及其配体FasL蛋白作为外源性凋亡途径代表,在多种肿瘤中均可表达,其不仅参与机体的免疫监视而且在肿瘤的发生、发展及转移过程中具有重要作用。BCL-2蛋白作为内源性凋亡途径的代表分子,其往往是通过抑制细胞凋亡参与癌症的,BCL-2蛋白在实体组织和淋巴样细胞的恶性转化中起关键作用。FAS/FAS-L蛋白与BCL2蛋白与卵巢癌的发生发展密不可分。本综述通过阅读大量文献,简要阐述了FAS/FAS-L蛋白及BCL2蛋白,并描述了FAS/FAS-L蛋白及BCL2蛋白在恶性卵巢肿瘤中表达状况及其与预后的关系,以及分析FAS/FAS-L蛋白与BCL2蛋白的在卵巢肿瘤表达中的相关性。

Apoptotic signaling pathway includes exogenous apoptotic pathway and endogenous apoptotic pathway. Fas and its ligand FasL protein, as the representative of exogenous apoptotic pathway, can be expressed in a variety of tumors. It not only participates in the immune monitoring of the body, but also plays an important role in the occurrence, development and metastasis of tumors. As a representative molecule of endogenous apoptosis pathway, Bcl-2 protein is often involved in cancer by inhibiting apoptosis. BCL2 protein plays a key role in the malignant transformation of solid tissue and lymphoid cells. Fas/Fas-L protein and BCL2 protein are closely related to the occurrence and development of ovarian cancer. This review briefly describes Fas/Fas-L protein and BCL2 protein through reading a large number of literatures, and describes the expression status of Fas/Fas-L protein and BCL2 protein in malignant ovarian tumors and their relationship with prognosis, as well as the correlation between Fas/Fas-L protein and BCL2 protein expression in ovarian tumors.