糖尿病合并新冠肺炎患者白细胞介素-6、白细胞介素-8、白细胞介素-10、TNF-α水平分析

Analysis of Interleukin-6, Interleukin-8, Interleukin-10 and TNF-α Levels in Patients with Diabetes Mellitus Complicated with New Crown Pneumonia

目的:探讨分析糖尿病合并新冠肺炎患者白细胞介素-6、白细胞介素-8、白细胞介素-10、TNF-α水平情况。方法:选取青岛大学附属医院援鄂医疗队在华中科技大学附属同济医院光谷院区2020年2月9日至2020年3月31日收治新冠病毒肺炎(COVID-2019)患者中75例,依据是否合并糖尿病分为COVID-2019组(n = 56)、合并组(n = 19),对比两组患者IL-6、IL-8、IL-10以及TNF-α指标水平。结果:两组患者IL-8、TNF-α指标对比无明显差异(P 】0.05);合并组患者IL-6、IL-10指标相比COVID-2019组明显更高(P 【0.05)。结论:COVID-2019合并糖尿病患者IL-8以及TNF-α指标与未合并糖尿病患者对比无显著差异,但合并组患者的IL-6、IL-10指标水平更高。

Objective: To investigate and analyze the levels of interleukin-6, interleukin-8, interleukin-10 and TNF-α in patients with diabetes complicated with new crown pneumonia. Methods: Seventy-five patients with newly diagnosed coronavirus pneumonia (COVID-2019) admitted by the Hubei Medical Team of the Affiliated Hospital of Qingdao University from February 9, 2020 to March 31, 2020 in the Guanggu Hospital of tongji hospital, affiliated to Huazhong University of Science and Technology were selected and divided into COVID-2019 group (n = 56) and combined group (n = 19) according to whether diabetes was complicated. The IL-6, IL-8, IL-10 and TNF-α index levels of the two groups of patients were compared. Results: There was no significant difference in the IL-8 and TNF-α indexes between the two groups of patients (P >0.05);the IL-6 and IL-10 indexes of the patients in the combined group were significantly higher than those in the COVID-2019 group (P <0.05). Conclusion: there is no significant difference in IL-8 and TNF-α indexes between COVID- 2019 patients with diabetes and patients without diabetes, but the level of IL-6, IL-10 indexes in patients with diabetes is higher.