新生儿外源性白蛋白的临床使用研究进展

Clinical Application and Research Progress of Exogenous Albumin in Neonates

白蛋白是血浆中含量最丰富的蛋白质之一,具有多种重要功能。新生儿血清白蛋白浓度随胎龄和出生后年龄变化较大。由于合成减少、白蛋白损失增加或重新分布至血管外间隙而发生低白蛋白血症,并与发病率和死亡率增加相关,因此,外源性白蛋白输注是数种新生儿疾病的抢救措施之一。但白蛋白输注可能启动高度复杂的过程,新生儿是特殊人群,在白蛋白的输注方面尚存在争议,但目前研究甚少,本文对新生儿临床使用白蛋白现状及相关进展进行综述。

Albumin is one of the most abundant proteins in plasma and has a variety of important functions. Neonatal serum albumin concentrations vary greatly with gestational age and postnatal age. As hypoalbuminemia occurs due to decreased synthesis, increased albumin loss, or redistribution to the extravascular space and is associated with increased morbidity and mortality, exogenous albumin infusion is one of the rescue measures for several neonatal diseases. However, albumin infusion may initiate a highly complex process, newborns are special populations, and there is still controversy in the infusion of albumin, but there are few studies at present, and this article reviews the current status and related progress in the clinical use of albumin in newborns.