FOXP1在卵巢癌中的作用及其机制

The Role and Mechanism of FOXP1 in Ovarian Cancer

卵巢癌缺少早期诊断方法,而晚期患者通过肿瘤细胞减灭术和基础化疗等传统治疗方案后易复发,因此从卵巢癌发生发展的分子机制探索新的分子标志物和治疗靶点意义重大。Forkhead Box P1 (FOXP1)作为转录因子密切参与卵巢癌的发生发展进程,近些年的研究表明,高表达的FOXP1通过促进上皮–间充质转化、调节肿瘤干细胞特性、调控多种分子信号转导通路等机制影响卵巢癌细胞增殖、转移、侵袭和化疗抗性。本文通过简要论述转录因子FOXP1在卵巢癌中的作用及其机制研究的最新进展,旨在为卵巢癌早期诊断和临床治疗寻找新的分子靶标。

There is a lack of early diagnosis of ovarian cancer, and advanced patients are prone to relapse after traditional treatment such as cytoreductive surgery and basic chemotherapy. Therefore, it is of great significance to explore new molecular markers and therapeutic targets from the molecular mechanism of ovarian cancer development. As a transcription factor, Forkhead Box P1 (FOXP1) is closely involved in the occurrence and development of ovarian cancer. Recent studies have shown that high expression of FOXP1 affects the proliferation, metastasis, invasion and chemotherapy resistance of ovarian cancer cells by promoting epithelial mesenchymal transition, regulating the characteristics of tumor stem cells, and regulating a variety of molecular signal transduction pathways. In this paper, we briefly discuss the role of FOXP1 in ovarian cancer and the latest progress of its mechanism, aiming to find a new molecular target for early diagnosis and clinical treatment of ovarian cancer.