细胞色素P450对器官移植的影响机制研究进展

Advances in the Mechanism of Cytochrome P450 on Organ Transplantation

肝、肾移植可用于终末期肝病患者和肾病患者的治疗,他克莫司广泛用于移植受者的免疫抑制药物,它治疗范围窄,个体间的药代动力学差异大,这种差异主要是细胞色素P450导致的,研究影响机制有利于制定个性化的用药方案,使患者获得更好的治疗效果。细胞色素P450对移植后并发症有重要影响,对影响机制的研究,可以及时发现并采取治疗措施,使患者有更好的预后。

Liver and kidney transplantation can be used for the treatment of patients with end-stage liver disease and kidney disease. Tacrolimus immunosuppressive drugs are widely used in transplant recipients. Its therapeutic scope is narrow and the pharmacokinetics vary greatly between individuals, mainly due to the cytochrome P450. The study of the influence mechanism is beneficial to the formulation of personalized drug use plan, so that patients can obtain better therapeutic effect. Cytochrome P450 plays an important role in complications after transplantation, and the study of its mechanism can help timely find out and take treatment measures, so that patients can have a better prognosis.