膜联蛋白A5在围生期疾病中的研究进展

The Research Progress of Annexin A5 in Perinatal Diseases

膜联蛋白A5 (Anx A5)是钙依赖的磷脂结合蛋白家族的一员,其广泛存在于组织细胞中,因为其具有的独特结构而参加多种细胞内、外的抗凝、促凋亡等重要功能。近年来研究发现,膜联蛋白A5在妊娠特发疾病如子痫前期、胎儿生长受限等孕妇的血清及胎盘组织中的表达下降,与多种疾病的发生发展密切相关。现就膜联蛋白A5的生物学功能及与各种妊娠相关疾病的关系进行分析与总结,为围生期相关疾病的预防及治疗提供新思路。

Annexin A5 (Anx A5) is a member of the calcium-dependent phospholipid binding protein family, which is widely present in tissues and cells. Because of its unique structure, it participates in a variety of important functions inside and outside the cell, such as anticoagulant and pro-apoptosis. In recent years, a large of number studies have showed that the expression of Annexin A5 in the serum and placental tissues of pregnant women with idiopathic pregnancy-related diseases such as preeclampsia, fetal growth restriction has decreased, which is closely related to the occurrence and development of many diseases. The biological function of Annexin A5 and the relationship with various pregnancy-related diseases are analyzed and summarized, which provides new ideas for the prevention and treatment of perinatal-related diseases.