Ninj1、IL-1β在子宫腺肌病和子宫内膜异位症中的表达及意义

Expression and Significance of Ninj1 and IL-1β in Adenomyosis and Endometriosis

子宫内膜异位症(endometriosis, EMs)是指子宫内膜组织(腺体和间质)在子宫腔被覆内膜及子宫以外的部位出现、生长、浸润,反复出血,继而引发疼痛、不孕及结节或包块等的妇科疾病。子宫腺肌病是指子宫内膜和子宫内膜间质的浸润,周围是非肿瘤性增生和肥厚的子宫肌层,从而导致与不育相关的子宫体积增加(对称或不对称),痛经和月经过多。目前的研究结论仍无法完全解释两种疾病的发病机制,因此内异症目前的治疗手段极其有限,并且无法完全治愈。近年研究发现两种疾病患者体内的免疫细胞及免疫因子的异常表达可能与这两种疾病的发生发展密切相关,而炎症介质是具有多种生物学功能的分子,其在子宫内膜异位症及子宫腺肌病的疼痛诱导和放大中的作用非常复杂。白细胞介素1β的异常升高可诱导子宫内膜炎症反应的启动;Ninj1既可以促进神经的生长,也可以通过介导白细胞迁移,进而介导炎症。本文就近年IL-1β及Ninj1在子宫腺肌病及子宫内膜异位症发病机制及疼痛症状中的作用研究进展进行综述,旨在为子宫腺肌病及子宫内膜异位症的诊治提供新的思路。

Endometriosis (EMs) refers to the appearance, growth and infiltration of endometrial tissues (glands and stroma) in the uterine cavity covering the endometrium and other parts of the uterus, repeated bleeding, and then causing pain, infertility and gynecological diseases such as nodules or masses. Adenomyosis refers to the infiltration of the endometrium and endometrial stroma, surrounded by non-neoplastic hyperplasia and hypertrophy of the myometrium, resulting in increased uterinevolume (symmetrical or asymmetrical) associated with infertility, dysmenorrhea and menstruation excessive. The current research conclusions still cannot fully explain the pathogenesis of the two diseases, so the current treatment methods for endometriosis are extremely limited and cannot be completely cured. In recent years, studies have found that the abnormal expression of immune cells and immune factors in patients with two diseases may be closely related to the occurrence and development of these two diseases. Inflammatory mediators are molecules with multiple biological functions, which are involved in endometriosis. And the role of pain induction and amplification in adenomyosis is very complicated. The abnormal increase of interleukin 1β can induce the initiation of endometrial inflammation;Ninj1 can not only promote the growth of nerves, but also mediate inflammation by mediating leukocyte migration. This article reviews the research progress of IL-1β and Ninj1 in the pathogenesis and pain symptoms of adenomyosis and endometriosis in recent years, aiming to provide diagnosis and treatment of adenomyosis and endometriosis new ideas.