摘要
Semaphorins家族是一类经典的神经元轴突导向排斥性因子。最近大量研究表明,该家族除了在神经系统发挥作用外,在肾脏发育与肾脏疾病中也起着重要作用及意义。在发育中的肾小球、成人足细胞及集合小管中均发现信号素3A (Semaphorin3A或Sema3A)及其受体neuropilin 1表达,该文将对现阶段Sema3A在肾脏发育及肾脏疾病所起作用最新研究进展进行综述。
The Semaphorins family is a classic class of neuronal axon-guided repulsion factors. A large number of recent studies have shown that the family plays an important role in the development of kidney and kidney disease in addition to its role in the nervous system. The expression of Semaphorin3A and its receptor Neuropilin 1 has been found in developing glomeruli, adult podocytes and collecting tubules. Here, we review the recent research progress of the Semaphorins family and the role of Sema3A in kidney development and kidney diseases.
出处
《临床医学进展》
2021年第9期4105-4112,共8页
Advances in Clinical Medicine
