赠卵辅助生殖HLA抗体相关性胎儿和新生儿同种免疫性血小板减少症1例并文献复习

Fetal and Neonatal Alloimmune Thrombocytopenia Due to HLA Alloimmunization in Oocyte Donation: A Case Report and Literature Review

胎儿和新生儿同种免疫性血小板减少症(Fetal and neonatal alloimmune thrombocytopenia, FNAIT)是妊娠或分娩后由相关抗体引起胎儿或新生儿血小板减少的重要原因。HLA抗体可引起胎儿或新生儿发生血小板减少。本文报告1例赠卵辅助生殖双胎之一新生儿合并HLA-A2、A68和B51抗体所致的同种免疫性血小板减少并中性粒细胞减少,其中HLA-A68抗体为首次报道,并结合国内外相关病例进行文献复习。

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an important cause of thrombocytopenia in fetal or neonatal caused by antibodies during pregnancy or after delivery. HLA antibodies can cause fetus or neonate thrombocytopenia. We reported a case of thrombocytopenia and neutropenia caused by HLA-A2, A68 and B51 antibodies in a neonate who was one of the twins of assisted reproduction with oocyte donation. The HLA-A68 antibodies were reported first, and the literature was reviewed in combination with relevant cases at home and abroad.