自噬,凋亡与骨肉瘤化疗耐药关系的研究进展

Research Progress on the Relationship between Autophagy, Apoptosis and Chemotherapy Resistance of Osteosarcoma

骨肉瘤是最常见的原发恶性骨肿瘤,侵袭性强、容易转移、预后差、发病机制并不明确。化疗是治疗中的难题。提升化疗敏感性,抵抗化疗耐药性是其中难题,自噬与凋亡与骨肉瘤的发生、发展、侵袭、治疗密切相关,骨肉瘤化疗耐药是多基因、多通路、多水平的复杂问题,自噬与凋亡相关基因与骨肉瘤化疗耐药密切相关。Livin基因与BCL-2通过凋亡途径参与了骨肉瘤化疗耐药,HMGB1通过调节自噬诱导骨肉瘤化疗耐药。自噬与凋亡的协同作用对肿瘤化疗耐药关系巨大。

Osteosarcoma is the most common primary malignant bone tumor with strong invasion, easy metastasis, poor prognosis and unclear pathogenesis. Chemotherapy is a difficult treatment. Improving the sensitivity of chemotherapy and resisting chemotherapy resistance is a difficult problem. Autophagy and apoptosis are closely related to the occurrence, development, invasion and treatment of osteosarcoma. Chemotherapy resistance of osteosarcoma is a complex problem with multiple genes, multiple pathways and multiple levels, and autophagy and apoptosis-related genes are closely related to chemotherapy resistance of osteosarcoma. Livin gene and BCL-2 are involved in chemotherapy resistance of osteosarcoma through apoptosis pathway, and HMGB1 induces chemotherapy resistance of osteosarcoma by regulating autophagy. The synergistic effect of autophagy and apoptosis has a great relationship with chemotherapy resistance of tumor.